USP37 Antibody - Cat. #: CSB-PA801223LA01HU

SKU: CSB-PA801223LA01HU

Size :50ug

Clone Number:

Aliases:Deubiquitinating enzyme 3 antibody; Deubiquitinating enzyme 37 antibody; EC 3.1.2.15 antibody; KIAA1594 antibody; MGC117261 antibody; OTTHUMP00000164146 antibody; tmp_locus_50 antibody; Ubiquitin carboxyl-terminal hydrolase 37 antibody; Ubiquitin specific peptidase 37 antibody; Ubiquitin specific processing protease 37 antibody; Ubiquitin specific protease 37 antibody; Ubiquitin thioesterase 37 antibody; Ubiquitin thiolesterase 37 antibody; Ubiquitin-specific-processing protease 37 antibody; UBP37_HUMAN antibody; USP37 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q86T82

Immunogen:Recombinant Human Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background:Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of \\\'Lys-11\\\'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of \\\'Lys-48\\\'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:USP37

Research Areas:Epigenetics and Nuclear Signaling; Cell biology