Tuberin-Specific antibody , Cat. # FNab09101

SKU: FNab09101

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.

Immunogen:tuberous sclerosis 2

Synonyms:FLJ43106, LAM, TSC2, TSC4, Tuberin, tuberous sclerosis 2, Tuberous sclerosis 2 protein

Observed MW:200 kDa

Uniprot ID:P49815

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IF, IHC

Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200?IF: 1:10-1:100

Gene ID:7249

Research Area:Cell Division and Proliferation