TRIB2 Monoclonal Antibody

SKU: BT-MCA4555

Size:100μL

Background:This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Research_area:Signal transduction, Cancer, Stem cells, Cardiovascular

Target_protein:TRIB2

applications:WB, ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:6A12A12B1

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:TRIB2

Immunogen:Purified recombinant fragment of human TRIB2 (AA: 1-200) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):38.8kDa

UniProt accession:Q92519

Synonyms:C5FW, TRB2, GS3955

GeneID:28951