TPMT Antibody - Cat. #: CSB-PA00585A0Rb

SKU: CSB-PA00585A0Rb

Size :50ug

Clone Number:

Aliases:HGNC:12014 antibody; S adenosyl L methionine thiopurine S methyltransferase antibody; Thiopurine methyltransferase antibody; Thiopurine S methyltransferase antibody; Thiopurine S-methyltransferase antibody; TPMT antibody; TPMT_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P51580

Immunogen:Recombinant Human Thiopurine S-methyltransferase protein (4-244AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000

Background:TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TPMT

Research Areas:Metabolism; Signal transduction