TOP2B Antibody - Cat. #: CSB-PA587958

SKU: CSB-PA587958

Size :100ul

Clone Number:

Aliases:Antigen MLAA 44 antibody; beta isozyme antibody; DNA topoisomerase 2 beta antibody; DNA topoisomerase 2-beta antibody; DNA topoisomerase II 180 kD antibody; DNA topoisomerase II antibody; DNA topoisomerase II beta antibody; DNA topoisomerase II beta isozyme antibody; Top 2 antibody; TOP 2B antibody; TOP IIB antibody; Top2 beta antibody; TOP2B antibody; TOP2B_HUMAN antibody; Top2beta antibody; TOPIIB antibody; Topo II beta antibody; Topoisomerase (DNA) II beta 180kDa antibody; Topoisomerase (DNA) II beta antibody; Topoisomerase IIb antibody; U937 associated antigen antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q02880

Immunogen:Synthesized peptide derived from Internal of Human topoisomerase II ?.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.RenM. Linka, Nucleic Acids Res., May 2007; 10.1093.John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587 - 5592. Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597 - 1607.Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301 - 4308.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TOP2B

Research Areas:Epigenetics and Nuclear Signaling;Cancer