TLR6 Antibody, Biotin conjugated - Cat. #: CSB-PA023605LD01HU

SKU: CSB-PA023605LD01HU

Size :50ug

Clone Number:

Aliases:CD286 antibody; CD286 antigen antibody; TLR 6 antibody; Tlr6 antibody; TLR6_HUMAN antibody; Toll like receptor 6 precursor antibody; Toll-like receptor 6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y2C9

Immunogen:Recombinant Human Toll-like receptor 6 protein (32-586AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Participates in the innate immune response to bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TLR6

Research Areas:Epigenetics and Nuclear Signaling; Cardiovascular; Immunology; Microbiology; Signal transduction