TK1 (Ab-13) Antibody - Cat. #: CSB-PA999799

SKU: CSB-PA999799

Size :100ul

Clone Number:

Aliases:cytosolic antibody; KITH_HUMAN antibody; Thymidine kinase 1 antibody; Thymidine kinase 1 soluble antibody; Thymidine kinase 1 soluble isoform antibody; Thymidine kinase antibody; Thymidine kinase cytosolic antibody; TK 1 antibody; TK 2 antibody; TK1 antibody; Tk1a antibody; Tk1b antibody; TK2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P04183

Immunogen:Synthesized non-phosphopeptide derived from Human TK around the phosphorylation site of serine 13 (P-G-S(p)-P-S).

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regulated in a cell cycle-dependent manner, accumulating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regulated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regulation remains elusive. These observations indicate that TK1 might be a useful marker of cell proliferation; however, recent studies have shown that TK1 plays a more significant role in the DNA damage response.

N Singh, Mol. Cell. Biol., May 1991; 11: 2362 - 2374.
Bin Tian, Am. J. Pathol., Aug 2003; 163: 789.
RenGerolami, Cancer Res., Feb 2000; 60: 993 - 1001.
Catia Traversari, Blood, Jun 2007; 109: 4708 - 4715

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TK1

Research Areas:Epigenetics and Nuclear Signaling