TICAM1 Antibody - Cat. #: CSB-PA023532KA01HU

SKU: CSB-PA023532KA01HU

Size :100ul

Clone Number:

Aliases:IIAE6 antibody; MGC35334 antibody; MyD88 3 antibody; Proline rich vinculin and TIR domain containing protein B antibody; Proline-rich antibody; PRVTIRB antibody; Putative NF kappa B activating protein 502H antibody; Putative NF-kappa-B-activating protein 502H antibody; Putative NFkB activating protein antibody; TCAM1_HUMAN antibody; TICAM 1 antibody; TICAM-1 antibody; Ticam1 antibody; TIR domain containing adapter molecule 1 antibody; TIR domain containing adapter protein inducing IFN beta antibody; TIR domain containing adaptor inducing interferon beta antibody; TIR domain-containing adapter molecule 1 antibody; TIR domain-containing adapter protein inducing IFN-beta antibody; Toll interleukin 1 receptor domain containing adapter protein inducing interferon beta antibody; Toll like receptor adaptor molecule 1 antibody; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibody; TRIF antibody; TRIF protein antibody; vinculin and TIR domain-containing protein B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8IUC6

Immunogen:Recombinant protein of Human TICAM1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Background:Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-?B and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of I?B that normally maintains NF-?B inactivity by sequestering it in the cytoplasm.TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-?B, IRF3 and trigger IFN-? production. Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively. TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-?B activation. In addition, TRIF can trigger signaling of that lead to the induction of apoptosis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Affinity purification

Conjugate:Non-conjugated

Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TICAM1

Research Areas:Immunology