Thyroid peroxidase/TPO Monoclonal Antibody

SKU: AN200225P

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Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:TPO

Target Synonym:TDH2A;MSA;PERT;Thyroid microsomal antigen;Thyroid peroxidase;Thyroperoxidase;TPX;TPO;MSA;PERT;TDH2A;Thyroid microsomal antigen;Thyroid peroxidase;Thyroperoxidase;TPO;TPX

Research Areas:Signal Transduction;Neuroscience;Cancer;Metabolism

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:IHC-P

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:4B16

UNIProt ID:P07202

Accession:

Background:Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx 100 kDa molecular weight. Thyroid peroxidase is an enzyme expressed abundantly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine or triiodothyronine, thyroid hormones. Thyroid peroxidase plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin to form precursors of the thyroid hormones T4 and T3.

Concentration:1 mg/mL

Immunogen:Recombinant Human Thyroid peroxidase/TPO Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:50-1:200

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