TET3 Antibody, FITC conjugated - Cat. #: CSB-PA023398LC01HU

SKU: CSB-PA023398LC01HU

Size :50ug

Clone Number:

Aliases:hCG_40738 antibody; KIAA0401 antibody; Methylcytosine dioxygenase TET3 antibody; Probable methylcytosine dioxygenase TET3 antibody; Tet methylcytosine dioxygenase 3 antibody; Tet oncogene family member 3 antibody; Tet3 antibody; TET3_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43151

Immunogen:Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TET3

Research Areas:Epigenetics and Nuclear Signaling