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GeneBio Systems

TERT Polyclonal Antibody

TERT Polyclonal Antibody

E-AB-12901

¥62,100 JPY
¥62,100 JPY
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Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:TERT

Target Synonym:CMM9;DKCA2;DKCB4;EST2;HEST2;htert;hTRT;PFBMFT1;TCS1;Telomerase associated protein 2;Telomerase catalytic subunit;Telomerase reverse transcriptase;Telomerase-associated protein 2;Telomere Reverse Transcriptase;TERT;TERT;TP2;TRT

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Developmental Biology;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O14746

Accession:

Background:Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Concentration:0.4 mg/mL

Immunogen:Synthetic peptide of human TERT

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW:

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