TAP2 Antibody, Biotin conjugated - Cat. #: CSB-PA22539D0Rb

SKU: CSB-PA22539D0Rb

Size :50ug

Clone Number:

Aliases:ABC transporter, MHC 2 antibody; ABC18 antibody; ABCB3 antibody; Antigen peptide transporter 2 antibody; APT2 antibody; ATP binding cassette, sub family B (MDR/TAP), member 3 antibody; ATP-binding cassette sub-family B member 3 antibody; D6S217E antibody; Peptide supply factor 2 antibody; Peptide transporter involved in antigen processing 2 antibody; Peptide transporter PSF2 antibody; Peptide transporter TAP2 antibody; PSF 2 antibody; PSF-2 antibody; PSF2 antibody; Really interesting new gene 11 protein antibody; RING 11 antibody; RING11 antibody; TAP 2 antibody; Tap2 antibody; TAP2_HUMAN antibody; Transporter 2 ATP binding cassette sub family B antibody; Transporter 2, ABC (ATP binding cassette antibody; Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q03519

Immunogen:Recombinant Human Antigen peptide transporter 2 protein (473-615AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TAP2

Research Areas:Tags & Cell Markers; Signal transduction