SUV39H2 Antibody - Cat. #: CSB-PA566420

SKU: CSB-PA566420

Size :100ul

Clone Number:

Aliases:FLJ23414 antibody; H3 K9 HMTase 2 antibody; H3-K9-HMTase 2 antibody; Histone H3 K9 methyltransferase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody; Histone lysine N methyltransferase SUV39H2 antibody; Histone-lysine N-methyltransferase SUV39H2 antibody; KMT1B antibody; Lysine N methyltransferase 1B antibody; Lysine N-methyltransferase 1B antibody; sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody; Su(var)3 9 Drosophila homolog of 2 antibody; Su(var)3 9 homolog 2 antibody; Su(var)3-9 homolog 2 antibody; Suppressor of variegation 3 9 homolog 2 antibody; Suppressor of variegation 3-9 homolog 2 antibody; Suv39h2 antibody; SUV92_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H5I1

Immunogen:Synthesized peptide derived from internal of Human SUV39H2.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Sugano S., Nat. Genet. 36:40-45(2004).
Venter J.C., Submitted (SEP-2005).
Schupp I., BMC Genomics 8:399-399(2007).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SUV39H2

Research Areas:Epigenetics and Nuclear Signaling