STIP1/HOP Rabbit pAb

SKU: ES20870

Size: 100μL

Source:Rabbit

Applications:IHC;WB

Reactivity:Human; Mouse;Rat

Dilution:IHC-p1:50-200 ,WB 1:1000-2000

Immunogen:Synthesized peptide derived from human STIP1/HOP AA range: 250-300

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):64kD

Human_gene_id:10963

Human_swiss_prot_no:P31948

Subcellular_location:Cytoplasm . Nucleus . Dynein axonemal particle .

Other_name:Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

Background:STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009],