STAT3 Monoclonal Antibody

SKU: BT-MCA2884

Size:100μL

Background:STAT3: signal transducer and activator of transcription 3 (acute-phase response factor). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Research_area:Signal Transduction

Target_protein:STAT3

applications:IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:7G3H4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:STAT3

Immunogen:Purified recombinant fragment of STAT3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P40763

Synonyms:APRF, HIES

GeneID:6774