Splicing factor 1(Phospho Ser82) Polyclonal Antibody

SKU: BT-AP01624

Size:100μL

Background:This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site| together with the large subunit of U2 auxiliary factor (U2AF)| and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif| a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence| a zinc knuckles domain| and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.

Research_area:Developmental biology; Epigenetics and nuclear signaling

Target_protein:SF1

applications:WB, IHC-p, IF, ICC, ELISA

Reactivity:Human, Mouse, Monkey

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Splicing factor 1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):68330

UniProt accession:Human: Q15637; Mouse: Q64213

Synonyms:Splicing factor 1; SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162

GeneID:Human: 7536