SPAG8 Antibody - Cat. #: CSB-PA269500

SKU: CSB-PA269500

Size :50ul

Clone Number:

Aliases:BS 84 antibody; CILD28 antibody; HSD 1 antibody; HSD-1 antibody; HSD1 antibody; hSMP1 antibody; MGC26201 antibody; MH SPAG8 antibody; OTTHUMP00000021352 antibody; OTTMUSP00000032209 antibody; SMP-1 antibody; SMP1 antibody; SPAG3 antibody; SPAG8 antibody; SPAG8_HUMAN antibody; Sperm associated antigen 8 antibody; Sperm associated antigen 8 like protein antibody; Sperm membrane protein 1 antibody; Sperm membrane protein BS-84 antibody; Sperm-associated antigen 8 antibody; Testicular tissue protein Li 177 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q99932

Immunogen:Fusion protein of Human SPAG8

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:25-1:100

Background:The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SPAG8

Research Areas:Cell biology;Stem cells