SNX3 rabbit pAb

SKU: ES7867

Size: 100μL

Source:Rabbit

Applications:WB;ELISA;IHC

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from human SNX3. AA range:91-140

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):18kD

Human_gene_id:8724

Human_swiss_prot_no:O60493

Subcellular_location:Early endosome . Cytoplasmic vesicle, phagosome . Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). .

Other_name:SNX3; Sorting nexin-3; Protein SDP3

Background:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],