SMAD2 Polyclonal Antibody

SKU: E-AB-70367

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:SMAD2

Target Synonym:Drosophila;homolog of;MADR2;hMAD-2;HsMAD2;JV18;JV18-1;JV181;MAD;MAD homolog 2;MAD Related Protein 2;Mad-related protein 2;MADH2;MADR2;MGC22139;MGC34440;Mother against DPP homolog 2;Mothers against decapentaplegic homolog 2;Mothers against decapentaplegic;Drosophila;homolog of;2;Mothers against DPP homolog 2;OTTHUMP00000163489;Sma and Mad related protein 2;Sma- and Mad-related protein 2 MAD;SMAD 2;SMAD family member 2;SMAD;mothers against DPP homolog 2;SMAD2;SMAD2

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Signal Transduction;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q15796,Q62432,O70436

Accession:

Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Concentration:500 μg/mL

Immunogen:Recombinant protein corresponding to MouseSmad2

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:WB 1:500-1:2000;IHC 1:300-1:800

Calculated MW:60kDa

ObservedMW:60kDa