SIRT7 Antibody - Cat. #: CSB-PA885703LA01HU

SKU: CSB-PA885703LA01HU

Size :50ug

Clone Number:

Aliases:NAD dependent deacetylase sirtuin 7 antibody; NAD dependent protein deacetylase sirtuin 7 antibody; NAD-dependent protein deacetylase sirtuin-7 antibody; Regulatory protein SIR2 homolog 7 antibody; Silent mating type information regulation 2 homolog antibody; Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody; SIR2 L7 antibody; SIR2 like protein 7 antibody; Sir2 related protein type 7 antibody; SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody; SIR2-like protein 7 antibody; SIR2L 7 antibody; SIR2L7 antibody; SIR7_HUMAN antibody; SIRT 7 antibody; SIRT7 antibody; Sirtuin 7 antibody; Sirtuin type 7 antibody; Sirtuin7 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NRC8

Immunogen:Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at \'Lys-18\' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SIRT7

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism