SH2D1A Antibody - Cat. #: CSB-PA021209LA01HU

SKU: CSB-PA021209LA01HU

Size :50ug

Clone Number:

Aliases:DSHP antibody; Duncan disease SH2 protein antibody; Duncan disease SH2-protein antibody; EBVS antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; SAP/SH2D1A antibody; SH2 domain containing 1A antibody; SH2 domain protein 1A antibody; SH2 domain-containing protein 1A antibody; SH21A_HUMAN antibody; SH2D1A antibody; Signaling lymphocyte activation molecule associated protein antibody; Signaling lymphocytic activation molecule-associated protein antibody; SLAM associated protein antibody; SLAM associated protein/SH2 domain protein 1A antibody; SLAM-associated protein antibody; T cell signal transduction molecule SAP antibody; T-cell signal transduction molecule SAP antibody; XLP antibody; XLPD antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60880

Immunogen:Recombinant Human SH2 domain-containing protein 1A protein (11-124AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SH2D1A

Research Areas:Cardiovascular; Immunology