SATB2 antibody , Cat. # FNab10798

SKU: FNab10798

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons(UL1) specific genetic program and for the inactivation of deep-layer neurons(DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

Immunogen:SATB homeobox 2

Synonyms:DNA binding protein SATB2, KIAA1034, SATB homeobox 2, SATB2

Observed MW:69-83 kDa

Uniprot ID:Q9UPW6

Reactivity:Human

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1?200-1?2000; IHC: 1?20-1?200

Gene ID:23314

Research Area:Neuroscience, Cancer, Metabolism, Developmental biology