SART3 antibody , Cat. # FNab07612

SKU: FNab07612

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation(PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites(PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly(PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair(PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC(By similarity).

Immunogen:squamous cell carcinoma antigen recognized by T cells 3

Synonyms:DSAP1, hSART 3, KIAA0156, P100, p110, p110(nrb), RP11 13G14, SART 3, SART3, TIP110,

Observed MW:110 kDa

Uniprot ID:Q15020

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

Gene ID:9733

Research Area:Metabolism