S100B Monoclonal Antibody

SKU: BT-MCA2363

Size:100μL

Background:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Research_area:Cell Biology, Signal Transduction, Epigenetics and Nuclear Signaling, Stem Cells

Target_protein:S100B

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4C7H12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:S100B

Immunogen:Purified recombinant fragment of human S100B (AA: 1-92) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):10.7kDa

UniProt accession:P04271

Synonyms:NEF, S100, S100-B, S100beta

GeneID: