RP1 Rabbit Polyclonal Antibody

SKU: BT-AP04532

Size:100μL

Background:This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains| which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein| another retinal-specific protein| play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels| this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found| which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However| the biological validity and full-length nature of some variants cannot be determined at this time.

Research_area:Developmental biology; Neuroscience

Target_protein:RP1

applications:WB

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:RP1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):237160

UniProt accession:Human: P56715; Mouse: P56716

Synonyms:RP1

GeneID:Human: 6101; Mouse: 19888