ROCK1 Polyclonal Antibody

SKU: E-AB-70124

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ROCK1

Target Synonym:coiled-coil-containing protein kinase 1;coiled-coil-containing protein kinase I;MGC131603;MGC43611;p160 Rhoassociated coiled coil-forming protein kinase;p160 ROCK-1;p160 ROCK1;p160ROCK;PRO0435;Renal carcinoma antigen NY REN 35;Renal carcinoma antigen NY-REN-35;Rho associated coiled coil containing protein kinase 1;Rho associated protein kinase 1;Rho kinase;Rho-alpha kinase;Rho-associated;Rho-associated protein kinase 1;ROCK I;ROCK-I;ROCK1;ROCK1;Rok;rokalpha

Research Areas:Cancer;Cell Biology;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P70335,Q63644

Accession:

Background:This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Concentration:300 μg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Mouse Rock1

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:100-1:400

Calculated MW:

ObservedMW: