Recombinant TPX2 Monoclonal Antibody

SKU: AN301679L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:TPX2

Target Synonym:FLS;HCA;TPX;HCTP;REPP;GD:C20orf;DIL;DIL2;p100;DIL-2;HCTP4;FLS353;HCA519;REPP86;C20orf1;C20orf2;GD:C20orf1;TPX2;Chromosome 20 Open Reading Frame 1;Differentially expressed in cancerous and noncancerous lung cells 2;Differentially expressed in cancerous and non-cancerous lung cells 2;Differentially expressed in lung cells;Differentially expressed in lung cells 2;DIL 2;HCA 519;HCTP 4;Hepatocellular carcinoma associated antigen 519;Hepatocellular carcinoma-associated antigen 519;Preferentially expressed in colorectal cancer;Protein fls353;REPP 86;Restricted expression proliferation associated protein 100;Restricted expression proliferation-associated protein 100;Targeting protein for Xklp2;TPX 2;TPX2 microtubule associated homolog;TPX2 microtubule associated protein homolog;TPX2 microtubule nucleation factor

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:IHC;IF;FCM;WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A382

UNIProt ID:Q9ULW0

Accession:

Background:Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

Concentration:1 mg/mL

Immunogen:Recombinant human TPX2 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:200;IF 1:50;FCM 1:50-1:100

Calculated MW:86 kDa

ObservedMW:100 kDa