Recombinant STING Monoclonal Antibody

SKU: AN301666L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:STING

Target Synonym:NET;TMEM;TMEM173;ERIS;MITA;MPYS;NET23;SAVI;STING;hMITA;hSTING;Mediator of IRF3 activation;Stimulator of interferon genes protein;STING1;endoplasmic reticulum IFN stimulator;Endoplasmic reticulum interferon stimulator;FLJ38577;Mitochondrial mediator of IRF3 activation;N terminal methionine proline tyrosine serine plasma membrane tetraspanner;Stimulator of interferon genes;TM173;Transmembrane protein 173

Research Areas:Immunology;Signal Transduction;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A369

UNIProt ID:Q86WV6

Accession:

Background:STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second messenger cGAMP; then the dimerized STING binds to cGAMP and undergoes conformational changes. Through the autophagsome and the endoplasmic reticulum and the Golgi apparatus, it further enters the cytoplasm. During the period, it is ubiquitinated and recruited TBK1 protein, then phosphorylated, and then combined with IRF3; then IRF3 is phosphorylated and enters the nucleus to induce the expression of IFNs, etc. In conclusion, it can enhance the body's immune ability and kill bacteria, viruses and other pathogens to a greater extent.

Concentration:1 mg/mL

Immunogen:Recombinant human STING fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:50

Calculated MW:42 kDa

ObservedMW:36 kDa