Recombinant SMARCC2/BAF170 Monoclonal Antibody

SKU: AN302065L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:SMARCC2/BAF170

Target Synonym:Rsc;BAF;CRACC;SMARCC;SMARCC2;BAF170;CRACC2;Rsc8

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC;FCM;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A785

UNIProt ID:Q8TAQ2

Accession:

Background:Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by alteringDNA-histone contacts within a nucleosome in an ATP-dependent manner. BAF170 is one of the core subunits of the SWI/SNF complex,which is necessary for efficient nucleosome remodeling by Brg1 in vitro. While BAF170 has been shown to be part of the SWI/SNF complexin non-pluripotent cells, it is absent in pluripotent embryonic stem (ES) cells. Research studies have shown that expression of BAF170 is upregulated in neurons/neuronal progenitors upon differentiation of mouse ES cells with retinoic acid, and exogenous expression of BAF170leads to loss of stem cell pluripotency and self renewal.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:2000;IHC 1:500-1:1000;FCM 1:100;IP 1:50-1:100

Calculated MW:133 kDa

ObservedMW:170 kDa