Recombinant SGK1 Monoclonal Antibody

SKU: AN301954L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:SGK1

Target Synonym:SGK1;SGK;OTTHUMP00000017247;Serine/threonine protein kinase SGK;Serine/threonine protein kinase Sgk1;Serine/threonine-protein kinase Sgk1;Serum and glucocorticoid regulated kinase;Serum/glucocorticoid regulated kinase;Serum/glucocorticoid regulated kinase 1;Serum/glucocorticoid-regulated kinase 1;SGK 1;Sgk1 variant i3

Research Areas:Signal Transduction;Stem Cells;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A670

UNIProt ID:O00141

Accession:

Background:Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation.In addition to its membrane channel and carrier functions, SGK1 also regulates a broad range of targets, such as GSK-3, NEDD4, iNOS, AMPAR, PSD95, Tau, NF-κB, CREB, and FKHR-L1.

Concentration:1 mg/mL

Immunogen:Recombinant human SGK1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000

Calculated MW:49 kDa

ObservedMW:45-55 kDa