Recombinant RING1B Monoclonal Antibody

SKU: AN301819L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:RING1B

Target Synonym:RNF;DinG;Ring1b;Rnf2

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IF;FCM

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A531

UNIProt ID:Q9CQJ4

Accession:

Background:RING1B is a E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It may be involved in the initiation of both imprinted and random X inactivation. It E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4.

Concentration:1 mg/mL

Immunogen:Recombinant human RING1B fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:200-1:1000;IF 1:50;FCM 1:50-1:100

Calculated MW:38 kDa

ObservedMW:38 kDa