Recombinant Rab8A Monoclonal Antibody

SKU: AN301923L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Rab8A

Target Synonym:RAB;RAB8A;MEL;RAB8;AA409338;Mel transforming oncogene;Mel transforming oncogene (derived from cell line NK14);Mel transforming oncogene (derived from cell line NK14) RAB8 homolog;Mel transforming oncogene (RAB8 homolog);MGC124948;Oncogene c mel;Oncogene c-mel;RAB8A member RAS oncogene family;Ras associated protein RAB8;Ras related protein Rab 8A;Ras-related protein Rab-8A

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;African green monkey

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A639

UNIProt ID:P61006

Accession:

Background:The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring. RAB8 has two isoforms, RAB8A and RAB8B, that share 40% amino acid identity in the C-terminal variable region. RAB8 activity is regulated by specific guanine nucleotide exchange factors (GEFs), that mediate GTP loading, and GTPase activating proteins (GAPs) that convert them into the inactive GDP-bound form. RAB8 participates in recycling of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to the dendritic spine surface as well as in the intracellular transport of the metabotropic glutamate receptor type 1 in neuronal cells. Rab8 is activated at the base of the cilium by its guanine nucleotide exchanger Rabin8.

Concentration:1 mg/mL

Immunogen:Recombinant human Rab8A fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:2000;IHC 1:50-1:100

Calculated MW:24 kDa

ObservedMW:24 kDa