Recombinant PPP1CB Monoclonal Antibody

SKU: AN301634L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:PPP1CB

Target Synonym:NSLH;PPP1CB;HEL-S-80p;PP-1B;PP1B;PP1beta;PPP1CD;NSLH2;beta isozyme;catalytic subunit;delta isoform;MGC3672;PP 1B;Protein phosphatase 1;Protein phosphatase 1 beta;Protein phosphatase 1 catalytic subunit beta isoform;Protein phosphatase 1 delta;Serine threonine protein phosphatase PP1 beta catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Research Areas:Signal Transduction;Cancer;Metabolism;Cell Biology;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IF;FCM;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A337

UNIProt ID:P62140

Accession:

Background:Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

Concentration:1 mg/mL

Immunogen:Recombinant human PPP1CB fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:200-1:500;FCM 1:50-1:100;IP 1:50-1:100

Calculated MW:37 kDa

ObservedMW:35 kDa