Recombinant Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody

SKU: AN300005L

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:ERBB2

Target Synonym:TKR;ERBB;erb-b2 receptor tyrosine kinase;Receptor tyrosine-protein kinase erbB;Tyrosine kinase-type cell surface receptor HER;HER2/ErbB;HER;MLN;ERBB2;CD340;HER-2;HER-2/neu;HER2;MLN 19;NEU;NGL;TKR1;erb-b2 receptor tyrosine kinase 2;HER2/ErbB2;MLN19;Metastatic lymph node gene 19 protein;p185;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2;Tyrosine kinase-type cell surface receptor HER2;Neu;erb-B2;CD340;erb-b2 receptor tyrosine kinase 2;HER2;HER-2;HER-2/neu;MLN 19;MLN19;NGL;TKR1;C erb B2/neu protein;CD340 antigen;Cerb B2/neu protein;CerbB2;ENV;ENVW;Erb b2 receptor tyrosine kinase 2;ERVWE1;HER 2;HER 2/NEU;Herstatin;HERV7Q;HERV-7q;HERVW;HERVWENV;HERV-W-ENV;Human epidermal growth factor receptor 2;NEU proto oncogene;neuro/glioblastoma derived oncogene homolog;neuro/glioblastoma derived oncogene homolog (avian);Neuroblastoma/glioblastoma derived oncogene homolog;p185erbB2;Proto-oncogene c-ErbB-2;Tyrosine kinase type cell surface receptor HER2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog);V erb b2 avian erythroblastic leukemia viral oncoprotein 2;V erb b2 erythroblastic leukemia viral oncogene homolog 2;Verb b2 erythroblastic leukemia viral oncogene homolog 2

Research Areas:Tags & Cell Markers;Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:1A9

UNIProt ID:P04626

Accession:

Background:ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

Concentration:1 mg/mL

Immunogen:A synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2.

Buffer:10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Purification method:Protein A

Dilution:WB 1:10000-1:200000;

Calculated MW:138 kDa

ObservedMW:220 kDa