Recombinant Pan Trk Monoclonal Antibody

SKU: AN301971L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Pan Trk

Target Synonym:NTRK;Neurotrophic Tyrosine Kinase Receptor Type;NTRK2;GP145-TrkB;TRKB;trk-B;OBHD;BDNF/NT-3 Growth Factors Receptor;Neurotrophic Tyrosine Kinase Receptor Type 2;TrkB Tyrosine Kinase;Tropomyosin-Related Kinase B;TrkB receptor

Research Areas:Neuroscience;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A687

UNIProt ID:Q16620

Accession:

Background:The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Neurotrophin signaling through these receptors regulates a number of physiological processes, such as cell survival, proliferation, neural development, and axon and dendrite growth and patterning. In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system. Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at these sites reflects TrkA kinase activity. Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas. Research studies suggest that expression of TrkA in neuroblastomas may be a good prognostic marker as TrkA signals growth arrest and differentiation of cells originating from the neural crest.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1000-1:2000;IHC 1:50-1:100

Calculated MW:92 kDa

ObservedMW:120-140 kDa