Recombinant Notch1 Monoclonal Antibody

SKU: AN301057L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Notch1

Target Synonym:TAN;AOS;AOVD;Activated NOTCH;Neurogenic locus Notch homolog protein;Translocation-associated notch protein TAN;NOTC;AOS5;AOVD1;TAN1;hN1;NOTCH1;Activated NOTCH1;notch 1;Neurogenic locus Notch homolog protein 1;NICD;NOTC1;Notch 1 intracellular domain;Notch homolog 1 translocation associated (Drosophila);Translocation-associated notch protein TAN-1;AOS5;AOVD1;hN1;notch 1;TAN1;Notch-1

Research Areas:Neuroscience;Epigenetics and Nuclear Signaling;Stem Cells;Cardiovascular;Developmental Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:8D5

UNIProt ID:P46531

Accession:

Background:Notch 1(NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Notch1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-5000

Calculated MW:273 kDa

ObservedMW:120 kDa