Recombinant MTAP Monoclonal Antibody

SKU: AN301807L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:MTAP

Target Synonym:HEL;MTAP;BDMF;DMSFH;DMSMFH;HEL-249;LGMBF;MSAP;c86fus;5' methylthioadenosine phosphorylase;5''-methylthioadenosine phosphorylase;Epididymis luminal protein 249;HEL 249;MeSAdo phosphorylase;Methylthioadenosine phosphorylase;MTA phosphorylase;MTAPase;S methyl 5 thioadenosine phosphorylase;S methyl 5' thioadenosine phosphorylase;S-methyl-5''-thioadenosine phosphorylase

Research Areas:Signal Transduction;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A519

UNIProt ID:Q13126

Accession:

Background:MTAP is an enzyme essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine. MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma, thereby implicating its potential function as a tumor suppressor.

Concentration:1 mg/mL

Immunogen:Recombinant human MTAP fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:3000;IHC 1:50-1:100

Calculated MW:31 kDa

ObservedMW:31 kDa