Recombinant Mouse RANTES/CCL5 protein

SKU: CD00253

Size:5 ug

Background:Chemokine (C-C motif) ligand 5 (CCL5) also known as RANTES is classified as a chemotactic cytokine or chemokine. It is encoded by the CCL5 gene in humans. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites which has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells. In addition, it also induces the proliferation and activation of certain natural-killer cells to form CHAK cells. Recombinant Mouse CCL5, a single non-glycosylated polypeptide, contains 68 amino acids and it shares 84 % and 100 % a.a. sequence identity with human and rat CCL5.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Regulation upon Activation Normal T cell Express Sequence/CCL5

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.-1 ng/ml.

Synonyms:RANTES/CCL5, MuRa, MuRantes, RA, RANTES, SISd, Scy, Scya5, TCP22, TCP228,Mouse

Endotoxin:Less than 1 EU/μg of rMuRANTES/CCL5 as determined by LAL method.

Storage:-20ºC

Sequence:SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

uniprot accession:P3882

Molecular weight:Approximately 7.9 kDa, a single non-glycosylated polypeptide chain containing 68 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 3 % Acetonitrile and .1 % TFA.