Recombinant Mouse PF-4/CXCL4 protein

SKU: CD00274

Size:5 ug

Background:CXCL4 (PF4) is a small cytokine belonging to the CXC chemokine family and it is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). This chemokine is released from alpha-granules of activated platelets during platelet aggregation and neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 interacts with a splice variant of the chemokine receptor CXCR3. Recombinant mouse CXCL4 contains 76 amino acids which is a single non-glycosylated polypeptide chain. Specifically, Human and mouse CXCL4 share about a 60 % identity.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Platelet Factor-4/CXCL4

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration of 1-1ng/ml.

Synonyms:PF-4/CXCL4,Cxcl, Cxcl4, Pf, Scyb, Scyb4, Mouse

Endotoxin:Less than 1 EU/μg of rMuPF-4/CXCL4 as determined by LAL method.

Storage:-20ºC

Sequence:VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES

uniprot accession:Q9Z126

Molecular weight:Approximately 8.2 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, 1.5 M NaCl, pH 7.4.