Recombinant Mouse KC/CXCL1 protein

SKU: CD00330

Size:5 ug

Background:Mouse CXCL1, also known as KC, is belonging to the CXC chemokine family. It is encoded by the GRO gene now designated CXCL1. The gene for CXCL1 was initially discovered in mouse fibroblasts by plateletderived growth factor. KC is member of the intercrine alpha (chemokine C-X-C) subfamily of chemokines. It is secreted by human melanoma cells, and also expressed by macrophages, neutrophils and epithelial cells. The functional receptor for CXCL1 has been identified as CXCR2. CXCL1 has chemotactic activity for neutrophils, and plays a role in inflammation and wound healing. Amino acid sequence of Mouse CXCL1 is approximately 60 % identical to the human CXCL1. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse KC/CXCL1

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1-1 ng/ml.

Synonyms:KC/CXCL1,Fsp, Gr, Gro1, KC, Mg, Mgsa, N5, N51, Scyb, Scyb1, gro, Mouse

Endotoxin:Less than 1 EU/μg of rMuKC/CXCL1 as determined by LAL method.

Storage:-20ºC

Sequence:APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK

uniprot accession:P1285

Molecular weight:Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.