Recombinant Mouse IL-17 RA/IL-17 R Protein(Fc Tag)

SKU: PDMM100153

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:IL-17 RA/IL-17 R

Target Synonym:Il17r;Il17ra;IL-7R;IL-17R; CDw217; IL-7RαAW538159;Cdw217;VDw217

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:Q60943

Accession:Q60943

Background:Interleukin-17 receptor (IL-17R) , also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217) , is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors , this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections , selective against Candida. It is characterized by persistent and/or recurrent infections of the skin , nails , and mucous membranes caused by organisms of the genus Candida , mainly Candida albicans.

Concentration:

Activity:Not validated for activity

Sequence:Ser32-Trp322

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:56.9 kDa

ObservedMW:80 kDa