Recombinant Mouse Ctla4 Protein(His Tag)

SKU: PDMM100100

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Immune Checkpoint Proteins

Abbreviation:Ctla4 CD152

Target Synonym:ALPS5;CD 152;CD;CD152;CD152 antigen;CD152 isoform;Celiac disease 3;CELIAC3;CTLA 4;CTLA-4;CTLA4;CTLA4;Cytotoxic T cell associated 4;Cytotoxic T lymphocyte antigen 4;Cytotoxic T lymphocyte associated 4;Cytotoxic T lymphocyte associated 4;soluble isoform;included;Cytotoxic T lymphocyte associated antigen 4;Cytotoxic T lymphocyte associated antigen 4 short spliced form;Cytotoxic T lymphocyte associated protein 4;Cytotoxic T lymphocyte associated serine esterase 4;Cytotoxic T lymphocyte protein 4;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;GRD4;GSE;ICOS;IDDM12;insulin-dependent diabetes mellitus 12;Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4;OTTHUMP00000216623

Research Areas:Cancer;Immunology;Stem cells

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:P09793

Accession:P09793

Background:Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Concentration:

Activity:Not validated for activity

Sequence:Glu36-Asp161

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:13.8 kDa

ObservedMW:20-30 kDa