Recombinant Mouse BLAME/SLAMF8 Protein(Fc Tag)

SKU: PDMM100133

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:BLAME/SLAMF8

Target Synonym:SLAM family member;SBBI;Slamf;B-lymphocyte activator macrophage expressed;CD353;SBBI42;SLAM family member 8;Blame;Slamf8; BLAME; SBBI42

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-Fc

UNIProt ID:Q9D3G2

Accession:Q9D3G2

Background:The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain , SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules , a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors , in association with SAP family adaptors , have crucial roles during normal immune reactions in innate and adaptive immune cells.Mouse SLAM family member 8 , also known as B-lymphocyte activator macrophage expressed , BCM-like membrane protein , SLAMF8 and BLAME , is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node , spleen , thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Concentration:

Activity:Not validated for activity

Sequence:Val21-Asp231

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:48.1 kDa

ObservedMW:56 kDa