Recombinant MEK5 Monoclonal Antibody

SKU: AN301907L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:MEK5

Target Synonym:MEK;MKK;MAP2K;MAPKK;PRKMK;MAP2K5;HsT17454;MAPKK5;MEK5;PRKMK5;MKK5;Dual specificity mitogen activated protein kinase kinase 5;Dual specificity mitogen-activated protein kinase kinase 5;EC 2.7.12.2;kinase 5;MAP kinase kinase 5;MAP kinase kinase MEK5b;MAPK/ERK kinase 5;MAPKK 5;MEK 5;mitogen-activated;mitogen-activated protein kinase kinase 5;MP2K5;Protein kinase;SAPKK5;SKK5

Research Areas:Signal Transduction;Cancer;Cardiovascular

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A623

UNIProt ID:Q13163

Accession:

Background:MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the MEK5-ERK5 pathway has been investigated as a strategy for cancer treatment. MEK5 is activated by a variety of stimuli, including growth factors, cytokines, and oxidative stress. Activation of MEK5 is triggered by upstream kinases MEKK2 and MEKK3, leading to phosphorylation of MEK5 at Ser311 and Thr315, which subsequently leads to MEK5 dependent phosphorylation of EKR5 at Thr218 and Tyr220. Phosphorylation of ERK5 leads to nuclear translocation and regulation of several oncogenic transcription factors, including MEF2C, c-Fos, c-Myc, and Sap1.

Concentration:1 mg/mL

Immunogen:Recombinant human MEK5 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000

Calculated MW:49, 50 kDa

ObservedMW:49, 50 kDa