Recombinant MDR1 Monoclonal Antibody

SKU: AN300819L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:MDR1

Target Synonym:MDR;PGY;ABC;ABCB;P-glycoprotein;Phospholipid transporter ABCB;ATP-dependent translocase ABCB;ATP-binding cassette sub-family B member;ABC20;CD243;CLCS;GP170;MDR1;P-GP;PGY1;P Glycoprotein;ABCB1;ATP-binding cassette sub-family B member 1;ATP-dependent translocase ABCB1;P-glycoprotein 1;Phospholipid transporter ABCB1;MDR-1;P-gp;gp170;ABC-B1;ATP binding cassette;Colchicin sensitivity;Doxorubicin resistance;member 1;Multidrug resistance 1;Multidrug resistance protein 1;P glycoprotein 1;P gp;sub family B (MDR/TAP)

Research Areas:Signal Transduction;Stem Cells;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5B3

UNIProt ID:P08183

Accession:

Background:The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human MDR1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:141 kDa

ObservedMW:141 kDa