Recombinant Latexin/LXN Monoclonal Antibody

SKU: AN300180P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:LXN

Target Synonym:ECI;Endogenous carboxypeptidase inhibitor;Latexin;Latexin protein;MUM;Protein MUM;TCI;Tissue carboxypeptidase inhibitor;LXN

Research Areas:Immunology;Tags & Cell Markers;Cell Biology;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;FCM;ICC/IF;IP

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:9B8

UNIProt ID:Q9BS40

Accession:

Background:Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin/LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in the human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including the brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. Also, Latexin is implicated in Alzheimer's disease.

Concentration:1 mg/mL

Immunogen:Recombinant Human Latexin / LXN Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;FCM 1:25-1:100;ICC/IF 1:20-1:100;IP 4-6 μL/mg of lysate

Calculated MW:25 kDa

ObservedMW:25 kDa