Recombinant Lamin A/C Monoclonal Antibody

SKU: AN300833L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Lamin A/C

Target Synonym:EMD;LDP;LMN;PRO;CDCD;LMNL;CMT2B;LMNA;CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;lamin;Lamin A/C;70 kDa lamin;Cardiomyopathy dilated 1A (autosomal dominant);Lamin A;Lamin A/C like 1;Lamin C;Lamin-A/C;Limb girdle muscular dystrophy 1B (autosomal dominant);LMN 1;LMN A;LMN C;Prelamin A/C;Renal carcinoma antigen NY REN 32;Renal carcinoma antigen NYREN32;Renal carcinoma antigen NY-REN-32;Lamin A/C (phospho Ser392)

Research Areas:Tags & Cell Markers;Signal Transduction;Cell Biology;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:2D5

UNIProt ID:P02545

Accession:

Background:Lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Lamin A/C protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:2000-1:10000

Calculated MW:74 kDa,63 kDa

ObservedMW:74 kDa,63 kDa