Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA, C-6His)

SKU: PKSH033991

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: TROP-2

Target Synonym: Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;TACSTD2;TROP2;Tumor-associated calcium signal transducer 2

Research Areas:

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application: BLI

Fusion tag: C-His

UNIProt ID: P09758

Accession: P09758

Background: Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.

Concentration:

Activity: Loaded Anti-Human TROP-2 mAb-Fc on Protein A Biosensor, can bind Human TROP-2-His with an affinity constant of 0.21 nM as determined in BLI assay.

Sequence: His27-Thr274

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 28.9 kDa

ObservedMW: 40-50 kDa