Recombinant Human SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His-Avi) Biotinylated

SKU: PKSH034057

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: SLAMF7;CD319;CRACC

Target Synonym: UNQ;PRO;SLAM;SLAMF7;19A;CD319;CRACC;CS1;19A24 protein;CD 319;CD2 like receptor activating cytotoxic cells;CD2 subset 1;CD2-Like Receptor-Activating Cytotoxic Cells;CD319 antigen;Membrane protein FOAP 12;Membrane Protein FOAP-12;Novel Ly9;Novel LY9 (lymphocyte antigen 9) like protein;Protein 19A;SLAM family member 7;SLAM7;SLAMF 7;UNQ576;PRO1138; CS1;CD319;CRACC;CS1;Novel Ly9

Research Areas: immunology

Conjugation: Biotinylated

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His-Avi

UNIProt ID: Q9NQ25

Accession: Q9NQ25

Background: SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Concentration:

Activity: Not validated for activity

Sequence: Ser23-Met226

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 25.2 kDa

ObservedMW: 35-55 kDa