Recombinant Human PTH7-34 protein

SKU: CD01028

Size:20 ug

Background:Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. It is a critical hormone in the regulation of Ca2+ homeostasis and secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. PTH (7-34), which is a PTH/PTHrP receptor antagonist, can stimulate hair growth and epidermal proliferation in mice.

Research_area:Others

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Parathyroid Hormone 7-34

Biological activity:Fully biologically active when compared to standard. The specific activity is determined by UMR16 cell/cAMP method, corresponding to a specific activity of > 1. × 14 IU/mg.

Synonyms:PTH,FIH1, PTH1, Human

Endotoxin:Less than 1EU/μg of rHuPTH7-34 as determined by LAL method.

Storage:-20ºC

Sequence:LMHNLGKHLN SMERVEWLRK KLQDVHNF

uniprot accession:P127

Molecular weight:Approximately 3.4 kDa, a single non-glycosylated polypeptide chain containing 28 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.